Droxinostat is a novel HDAC inhibitor. It selectively inhibits HDAC3, HDAC6, and HDAC8 with an IC50 of 16.9, 2.47 and 1.46 µM/L, respectively, but did not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10, with an IC50 of >20 µM/L.


Synonyms: 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide
Technical Data: Molecular Weight - 243.69; Molecular formula - C11H14ClNO3; CAS No - 99873-43-5

Ordering Information: Product Number - EC-000.2480
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1. Wood TE, Dalili S, Simpson CD, et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.

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Related service: collection of Histone Deacetylase Inhibitors.