ITF2357 is an inhibitor of HDAC activity (class I and class II HDAC) but also is an anti-inflammatory agent in vitro and in vivo. Enzymatically, ITF2357 inhibits different histone deacetylases from maize, and biochemical analysis revealed that, similar to SAHA, ITF2357 hyperacetylates histones in human PBMCs.

Givinostat, ITF-2357, Gavinostat, ITF2357

Synonyms: ITF-2357; Gavinostat; ITF2357
Technical Data: Molecular Weight - 421.50; Molecular formula - C24H27N3O4; CAS No - 732302-99-7

Ordering Information: Product Number - EC-000.2471
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1. Flavio Leoni, Gianluca Fossati, et al. The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo. Mol Med. 2005 Jan–Dec; 11(1-12): 1–15.
2. Shein NA, Grigoriadis N, et al. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J. 2009 Dec;23(12):4266-75.

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Related service: collection of Histone Deacetylase Inhibitors.