Belinostat is a novel hydroxamate-type inhibitor of histone deacetylase activity. It inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Belinostat is cytotoxic in vitro in a number of tumor cell lines with IC50s in the range 0.2-3.4 µM as determined by a clonogenic assay and induces apoptosis. This hdac inhibitor is currently under phase I/II testing in lymphoma, ovarian cancer and other solid tumors.


Synonyms: Belinostat; PXD101; PX105684; (E)-N-hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide
Technical Data: Molecular Weight - 318.35; Molecular formula - C15H14N2O4S; CAS No - 414864-00-9

Ordering Information: Product Number - EC-000.2286
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1. Plumb JA, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther. 2003 Aug;2(8):721-8.
2. Zain JM, et al. Targeted treatment and new agents in peripheral T-cell lymphoma. Int J Hematol. 2010 Jun 10.
3. Ramalingam SS, et al. Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesothelioma. J Thorac Oncol. 2009 Jan;4(1):97-101.

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Related service: collection of Histone Deacetylase Inhibitors.

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