Tubastatin A hydrochloride

Tubastatin A (CAS 1239262-52-2) is a potent and selective HDAC6 inhibitor. Demonstrates 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. This compound displayed dose-dependent protection against HCA induced neuronal cell death starting at 5 µM with near complete protection at 10 µM.

Tubastatin A structure

Synonyms: Tubastatin A; N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)-benzamide
Technical Data: Molecular Weight - 335.41; Molecular formula - C20H21N3O2; CAS No - 1239262-52-2

Ordering Information: Product Number - EC-000.2473
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This product is available to buy in bulk quantities.

References:
1. Butler, K.V., Kalin, J., Brochier, C., et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A. J Am Chem Soc (2010).
2. Wang Z., Leng Y., Wang J. Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of alpha-tubulin acetylation and FGF-21 up-regulation. Sci Rep. 2016;6:19626.
3. Zhang L. et al. Tubastatin A/ACY-1215 Improves Cognition in Alzheimer’s Disease Transgenic Mice. J Alzheimers Dis 41, 1193–1205 (2014).

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