The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation. Salermide (CAS 1105698-15-4) is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 µM) by reactivating proapototic genes that are repressed by SIRT1. Salermide is a stronger Sirtuin inhibitor than sirtinol.

Salermide HDAC Inhibitor

Synonyms: Salermide; (E)-N-(3-((2-hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide
Technical Data: Molecular Weight - 394.48; Molecular formula - C26H22N2O2; CAS No - 1105698-15-4

Ordering Information: Product Number - EC-000.2468
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1. Yamamoto, H., Schoonjans, K., Auwerx, J.. Sirtuin functions in health and disease. Mol Endocrinol 21(8) 1745-1755 (2007).
2. Milne, J.C., Denu, J.M.. The sirtuin family:Therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12 11-17 (2008).

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Related service: collection of Histone Deacetylase Inhibitors.